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The antibody against MITD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human MITD1 (NP_620153.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against MITD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human MITD1 (NP_620153.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-07312A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MITD1 |
| Target Synonyms | MITD1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | MCF7, Mouse spleen, Mouse thymus, Rat spleen, Rat thymus, U-87MG | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human MITD1 (NP_620153.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WV92 | Immunogen Sequence |
Uniprot Id
Q8WV92
Target Species
Human
Target Name
MITD1
Target Full Name
MIT domain-containing protein 1
Target Function
Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.
Target Subcellular Location
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.
Target Synonyms
MITD1MIT domain-containing protein 1
Target Background
Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene.
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