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The antibody against MSL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 328-577 of human MSL2 (NP_060603.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MSL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 328-577 of human MSL2 (NP_060603.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03432A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MSL2 |
| Target Synonyms | MSL-2; MSL2L1; RNF184; MSL2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, Mouse brain, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 328-577 of human MSL2 (NP_060603.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HCI7 | Immunogen Sequence |
Uniprot Id
Q9HCI7
Target Species
Human
Target Name
MSL2
Target Full Name
E3 ubiquitin-protein ligase MSL2
Target Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Target Protein Families
MSL2 family
Target Synonyms
Male specific lethal 2 homolog (Drosophila); Male specific lethal 2 homolog 1; Male specific lethal 2 homolog; Male specific lethal 2 like 1; Male-specific lethal 2 homolog; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; MSL-2; MSL2; MSL2-like 1; MSL2_HUMAN; MSL2L1; Ring finger protein 184
Target Background
Predicted to enable ubiquitin protein ligase activity. Involved in histone H4-K16 acetylation. Part of MSL complex.
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