Rabbit anti-Human PARP10 Polyclonal Antibody

The antibody against PARP10 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PARP10 (NP_116178.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03256A

Number

Cat.No	ADA-03256A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PARP10
Target Synonyms	ARTD10; PARP10	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, HepG2, HT-29, MCF7	Application	ELISA, WB

Cat.No

ADA-03256A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PARP10

Target Synonyms

ARTD10; PARP10

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, HepG2, HT-29, MCF7

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PARP10 (NP_116178.2).	Target Species	Human
Uniprot ID	Q53GL7	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PARP10 (NP_116178.2).

Target Species

Human

Uniprot ID

Q53GL7

Immunogen Sequence

Background Information

Uniprot Id

Q53GL7
Target Species

Human
Target Name

PARP10
Target Full Name

Protein mono-ADP-ribosyltransferase PARP10
Target Function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA.
Target Subcellular Location

Nucleus, nucleolus. Cytoplasm.
Target Tissue Specificity

Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

PARP10; Protein mono-ADP-ribosyltransferase PARP10; EC 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 10; ARTD10; Poly [ADP-ribose] polymerase 10; PARP-10
Target Background

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).

Rabbit anti-Human PARP10 Polyclonal Antibody

Specifications

Immunogen Information

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