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The antibody against PDE1B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 190-536 of human PDE1B (NP_000915.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against PDE1B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 190-536 of human PDE1B (NP_000915.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-04408A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE1B |
| Target Synonyms | PDE1B1; PDES1B; HEL-S-79p; PDE1B | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain, Mouse spinal cord, Mouse spleen, NCI-H460, THP-1 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 190-536 of human PDE1B (NP_000915.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q01064 | Immunogen Sequence |
Uniprot Id
Q01064
Target Species
Human
Target Name
PDE1B
Target Full Name
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Target Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
Target Synonyms
PDE1B1; PDES1B; HEL-S-79p; PDE1B
Target Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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