Rabbit anti-Human PI4KA Polyclonal Antibody

Uniprot Id

P42356

Target Species

Human

Target Name

PI4KA

Target Full Name

Phosphatidylinositol 4-kinase alpha

Target Function

Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.

Target Involvement

Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis (PMGYCHA)

Target Subcellular Location

Cytoplasm. Cell membrane.

Target Protein Families

PI3/PI4-kinase family, Type III PI4K subfamily

Target Tissue Specificity

Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes.

Target Synonyms

EC 2.7.1.67 ; Phosphatidylinositol 4 kinase alpha; Phosphatidylinositol 4 kinase catalytic alpha polypeptide; Phosphatidylinositol 4-kinase alpha; PI4 kinase; PI4-kinase alpha; PI4K ALPHA ; PI4K-alpha; pi4K230; PI4KA; PI4KA_HUMAN; PIK4; PIK4CA; PtdIns 4 kinase; PtdIns-4-kinase alpha

Target Background

This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4, 5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.