Rabbit anti-Human POLE3 Polyclonal Antibody

The antibody against POLE3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human POLE3 (NP_059139.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-16917A

Number

Cat.No	ADA-16917A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	POLE3
Target Synonyms	p17; YBL1; CHRAC2; CHRAC17; CHARAC17; E3	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, HepG2, Mouse bone marrow, Mouse spleen, Mouse testis	Application	ELISA, WB

Cat.No

ADA-16917A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

POLE3

Target Synonyms

p17; YBL1; CHRAC2; CHRAC17; CHARAC17; E3

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, HepG2, Mouse bone marrow, Mouse spleen, Mouse testis

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human POLE3 (NP_059139.3).	Target Species	Human
Immunogen Sequence	MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEEVDN	Uniprot ID	Q9NRF9

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human POLE3 (NP_059139.3).

Target Species

Human

Immunogen Sequence

MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEEVDN

Uniprot ID

Q9NRF9

Background Information

Uniprot Id

Q9NRF9
Target Species

Human
Target Name

POLE3
Target Full Name

DNA polymerase epsilon subunit 3
Target Function

Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Target Synonyms

Arsenic transactivated protein; Arsenic-transactivated protein; ASTP; CHARAC 17; CHARAC17; CHRAC 17 ; CHRAC-17; CHRAC17; Chromatin Accessibility Complex 17; Chromatin accessibility complex 17 kDa protein; DNA Polymerase Epsilon p17 Subunit; DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; DNA polymerase II subunit 3; DPOE3_HUMAN; Histone fold protein CHRAC17; HuCHRAC 17; HuCHRAC17; p17; p17 subunit; POL E3; POLE 3; POLE3; Polymerase (DNA directed) epsilon 3; YBL 1; YBL1
Target Background

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.

Rabbit anti-Human POLE3 Polyclonal Antibody

Specifications

Immunogen Information

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