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The antibody against PPM1K was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 89-351 of human PPM1K (NP_689755.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PPM1K was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 89-351 of human PPM1K (NP_689755.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using PPM1K Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
| Cat.No | ADA-08712A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPM1K |
| Target Synonyms | BDP; PTMP; PP2Cm; MSUDMV; PP2Ckappa; UG0882E07; PPM1K | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Daudi, Jurkat, Mouse liver, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 89-351 of human PPM1K (NP_689755.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N3J5 | Immunogen Sequence |
Uniprot Id
Q8N3J5
Target Species
Human
Target Name
PPM1K
Target Full Name
Protein phosphatase Mn(2+)-dependent 1K
Target Function
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
Target Involvement
Maple syrup urine disease, mild variant (MSUDMV)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
PP2C family
Target Synonyms
BDP; mitochondrial; MSUDMV; PP2C domain containing protein phosphatase 1K; PP2C domain-containing protein phosphatase 1K; PP2C kappa; PP2C like mitochondrial protein; PP2C type mitochondrial phosphoprotein phosphatase; PP2C-kappa; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PP2Ckappa; PP2CM; PPM1K; PPM1K_HUMAN; Protein phosphatase 1K; Protein phosphatase 1K; mitochondrial; Protein phosphatase 2C isoform kappa; Protein phosphatase Mg2+/Mn2+ dependent 1K; PTMP; UG0882E07
Target Background
This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore.
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