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The antibody against PROP1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PROP1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04154A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PROP1 |
| Target Synonyms | CPHD2; PROP-1; PROP1 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | GGGRSRFSPQGGQRGRPHSRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPLAHLSPAAFSSFLPES | Uniprot ID | O75360 |
Uniprot Id
O75360
Target Species
Human
Target Name
PROP1
Target Full Name
Homeobox protein prophet of Pit-1
Target Function
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
Target Involvement
Pituitary hormone deficiency, combined, 2 (CPHD2)
Target Subcellular Location
Nucleus.
Target Protein Families
Paired homeobox family
Target Tissue Specificity
Expressed specifically in embryonic pituitary.
Target Synonyms
PROP1; Homeobox protein prophet of Pit-1; PROP-1; Pituitary-specific homeodomain factor
Target Background
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
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