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The antibody against QPCT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against QPCT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-11081A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | QPCT |
| Target Synonyms | QC; GCT; sQC; QPCT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Rat liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q16769 | Immunogen Sequence |
Uniprot Id
Q16769
Target Species
Human
Target Name
QPCT
Target Full Name
Glutaminyl-peptide cyclotransferase
Target Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Target Subcellular Location
Secreted.
Target Protein Families
Glutaminyl-peptide cyclotransferase family
Target Research Area
Neuroscience
Target Synonyms
5730422A13Rik; EC; GCT; Glutaminyl cyclase; Glutaminyl peptide cyclotransferase; Glutaminyl tRNA cyclotransferase; Glutaminyl-peptide cyclotransferase; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; QC; qpct; QPCT_HUMAN; sQC
Target Background
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
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