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The antibody against RBL2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 413-613 of human RBL2 (NP_005602.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against RBL2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 413-613 of human RBL2 (NP_005602.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-10290A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RBL2 |
| Target Synonyms | Rb2; P130; BRUWAG; RBL2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Neuro-2a | Application | ELISA, WB, IF/ICC |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 413-613 of human RBL2 (NP_005602.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q08999 | Immunogen Sequence |
Uniprot Id
Q08999
Target Species
Human
Target Name
RBL2
Target Full Name
Retinoblastoma-like protein 2
Target Function
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Target Subcellular Location
Nucleus.
Target Protein Families
Retinoblastoma protein (RB) family
Target Research Area
Cancer
Target Synonyms
130 kDa retinoblastoma associated protein; 130 kDa retinoblastoma-associated protein; IB4; p130; PPAR-alpha-interacting complex protein 128; PRB2; Rb2; Rbl2; RBL2_HUMAN; RBR 2; RBR-2; RBR2; Retinoblastoma like 2; Retinoblastoma-like protein 2; Retinoblastoma-related protein 2; RIC128
Target Background
Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen.
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