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The antibody against RIF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 2173-2472 of human RIF1 (NP_060621.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RIF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 2173-2472 of human RIF1 (NP_060621.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10132A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RIF1 |
| Target Synonyms | RIF1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, LO2, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 2173-2472 of human RIF1 (NP_060621.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q5UIP0 | Immunogen Sequence |
Uniprot Id
Q5UIP0
Target Species
Human
Target Name
RIF1
Target Full Name
Telomere-associated protein RIF1
Target Function
Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs. Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase. Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Promotes NHEJ of dysfunctional telomeres
Target Subcellular Location
Nucleus. Chromosome. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle.
Target Protein Families
RIF1 family
Target Tissue Specificity
Highly expressed in testis.
Target Synonyms
DKFZp781N1478; FLJ10599; FLJ11269 ; FLJ12870; Rap1 interacting factor 1; Rap1 interacting factor 1 homolog; RAP1 interacting factor homolog ; RAP1 interacting factor homolog (yeast); Rap1-interacting factor 1 homolog; Receptor interacting factor 1; RIF 1; RIF1; RIF1 isoform 4 ; RIF1_HUMAN; Telomere associated protein RIF 1; Telomere associated protein RIF1; Telomere-associated protein RIF1; Telomeric protein RIF 1; Telomeric protein RIF1
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