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Rabbit anti-Human RNH1 Polyclonal Antibody

The antibody against RNH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-09770A

The antibody against RNH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

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Specifications


Cat.No ADA-09770A ClonalityPolyclonal
Host SpeciesRabbitTarget NameRNH1
Target SynonymsRAI; RNH; RNH1FormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesHeLa, Mouse kidney, Rat brain, HT-29, Mouse liver, Mouse lung, Raji, Rat lung, U-87MGApplicationELISA, WB, IF/ICC

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2).Target SpeciesHuman
Uniprot IDP13489Immunogen Sequence
Background Information
  • Uniprot Id

    P13489

  • Target Species

    Human

  • Target Name

    RNH1

  • Target Full Name

    Ribonuclease inhibitor

  • Target Function

    Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

  • Target Subcellular Location

    Cytoplasm.

  • Target Research Area

    Cardiovascular

  • Target Synonyms

    AW546468; C80305; MGC18200; MGC4569; MGC54054; OTTHUMP00000147628; OTTHUMP00000229864; OTTHUMP00000229865; OTTHUMP00000229866; OTTHUMP00000229870; OTTHUMP00000229871; OTTHUMP00000229872; Placental ribonuclease inhibitor; Placental RNase inhibitor; PRI; RAI; RI; Ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1; Ribonuclease/angiogenin inhibitor; RINI_HUMAN; RNase inhibitor; RNH 1; RNH; RNH1; Rnh1 ribonuclease/angiogenin inhibitor 1

  • Target Background

    Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50, 000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.

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