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The antibody against RNH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against RNH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09770A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNH1 |
| Target Synonyms | RAI; RNH; RNH1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Rat brain, HT-29, Mouse liver, Mouse lung, Raji, Rat lung, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P13489 | Immunogen Sequence |
Uniprot Id
P13489
Target Species
Human
Target Name
RNH1
Target Full Name
Ribonuclease inhibitor
Target Function
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
Target Subcellular Location
Cytoplasm.
Target Research Area
Cardiovascular
Target Synonyms
AW546468; C80305; MGC18200; MGC4569; MGC54054; OTTHUMP00000147628; OTTHUMP00000229864; OTTHUMP00000229865; OTTHUMP00000229866; OTTHUMP00000229870; OTTHUMP00000229871; OTTHUMP00000229872; Placental ribonuclease inhibitor; Placental RNase inhibitor; PRI; RAI; RI; Ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1; Ribonuclease/angiogenin inhibitor; RINI_HUMAN; RNase inhibitor; RNH 1; RNH; RNH1; Rnh1 ribonuclease/angiogenin inhibitor 1
Target Background
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50, 000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.
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