Rabbit anti-Human SEC14L2 Polyclonal Antibody

Uniprot Id

O76054

Target Species

Human

Target Name

SEC14L2

Target Full Name

SEC14-like protein 2

Target Function

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

Target Subcellular Location

Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.

Target Tissue Specificity

Widely expressed. Strong expression in liver, brain and prostate.

Target Synonyms

Alpha tocopherol associated protein; Alpha-tocopherol-associated protein; C22orf6 ; hTAP; KIAA1186 ; KIAA1658 ; MGC65053 ; OTTHUMP00000198972; OTTHUMP00000198973; OTTHUMP00000198974; OTTHUMP00000199021; S14L2_HUMAN; SEC14 (S. cerevisiae) like 2; SEC14 like 2 (S. cerevisiae) ; SEC14 like protein 2; SEC14-like protein 2; Sec14l2; SPF; Squalene transfer protein; Supernatant protein factor; TAP; TAP1 ; tocopherol-associated protein

Target Background

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.