Rabbit anti-Human Sec23A Monoclonal Antibody

Uniprot Id

Q15436

Target Species

Human

Target Name

SEC23A

Target Full Name

Protein transport protein Sec23A

Target Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane.

Target Involvement

Craniolenticulosutural dysplasia (CLSD)

Target Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.

Target Protein Families

SEC23/SEC24 family, SEC23 subfamily

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

CLSD; Protein transport protein Sec23A; SC23A_HUMAN; Sec23 homolog A (S. cerevisiae); SEC23-related protein A; sec23a

Target Background

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.