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The antibody against SFXN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 87-322 of human SFXN1 (NP_073591.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SFXN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 87-322 of human SFXN1 (NP_073591.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of Mouse kidney, using SFXN1 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
| Cat.No | ADA-03352A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SFXN1 |
| Target Synonyms | TCC; SLC56A1; SFXN1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 87-322 of human SFXN1 (NP_073591.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H9B4 | Immunogen Sequence |
Uniprot Id
Q9H9B4
Target Species
Human
Target Name
SFXN1
Target Full Name
Sideroflexin-1
Target Function
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine. May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria.
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
Sideroflexin family
Target Tissue Specificity
Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney.
Target Synonyms
SFXN1; Sideroflexin-1
Target Background
Enables D-serine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in D-serine transport; L-serine transport; and serine import into mitochondrion. Located in mitochondrion. Is integral component of mitochondrial inner membrane.
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