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The antibody against SNUPN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human SNUPN (NP_005692.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SNUPN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human SNUPN (NP_005692.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06073A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SNUPN |
| Target Synonyms | KPNBL; RNUT1; Snurportin1; SNUPN | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, 293T, Mouse brain, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human SNUPN (NP_005692.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O95149 | Immunogen Sequence |
Uniprot Id
O95149
Target Species
Human
Target Name
SNUPN
Target Full Name
Snurportin-1
Target Function
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
Snurportin family
Target Synonyms
0610031A09Rik; KPNBL; MGC134006; MGC95000; RNA U transporter 1; RNA, U transporter 1; RNUT 1; RNUT1; SNUPN; Snupn1; Snurportin 1; Snurportin-1; Snurportin1; SPN1; SPN1_HUMAN; wu:fc41a03; zgc:77819
Target Background
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2, 2, 7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
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