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The antibody against SOS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1034-1333 of human SOS1 (NP_005624.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SOS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1034-1333 of human SOS1 (NP_005624.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09806A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SOS1 |
| Target Synonyms | GF1; HGF; NS4; GGF1; GINGF; SOS-1; SOS1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, Mouse liver, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1034-1333 of human SOS1 (NP_005624.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q07889 | Immunogen Sequence |
Uniprot Id
Q07889
Target Species
Human
Target Name
SOS1
Target Full Name
Son of sevenless homolog 1
Target Function
Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.
Target Involvement
Fibromatosis, gingival, 1 (GINGF1); Noonan syndrome 4 (NS4)
Target Tissue Specificity
Expressed in gingival tissues.
Target Synonyms
GF1; HGF; NS4; GGF1; GINGF; SOS-1; SOS1
Target Background
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
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