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The antibody against SPATA7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-599 of human SPATA7 (NP_060888.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SPATA7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-599 of human SPATA7 (NP_060888.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05750A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPATA7 |
| Target Synonyms | HSD3; LCA3; RP94; HSD-3.1; HEL-S-296; SPATA7 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain, Mouse testis, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 300-599 of human SPATA7 (NP_060888.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9P0W8 | Immunogen Sequence |
Uniprot Id
Q9P0W8
Target Species
Human
Target Name
SPATA7
Target Full Name
Spermatogenesis-associated protein 7
Target Function
Involved in the maintenance of both rod and cone photoreceptor cells. It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC. Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration.
Target Involvement
Leber congenital amaurosis 3 (LCA3); Retinitis pigmentosa autosomal recessive (ARRP)
Target Subcellular Location
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Cell projection, cilium, photoreceptor outer segment.
Target Synonyms
SPATA7; HSD3; Spermatogenesis-associated protein 7; HSD-3.1; Spermatogenesis-associated protein HSD3
Target Background
This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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