Rabbit anti-Human SPG11 Polyclonal Antibody

The antibody against SPG11 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01425A

Number

Cat.No	ADA-01425A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SPG11
Target Synonyms	ALS5; CMT2X; KIAA1840; SPG11	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	U-87MG	Application	ELISA, WB

Cat.No

ADA-01425A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SPG11

Target Synonyms

ALS5; CMT2X; KIAA1840; SPG11

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3).	Target Species	Human
Uniprot ID	Q96JI7	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3).

Target Species

Human

Uniprot ID

Q96JI7

Immunogen Sequence

Background Information

Uniprot Id

Q96JI7
Target Species

Human
Target Name

SPG11
Target Full Name

Spatacsin
Target Function

May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.
Target Involvement

Spastic paraplegia 11, autosomal recessive (SPG11); Amyotrophic lateral sclerosis 5, juvenile (ALS5); Charcot-Marie-Tooth disease 2X (CMT2X)
Target Subcellular Location

Cytoplasm, cytosol. Nucleus. Cell projection, axon. Cell projection, dendrite.
Target Tissue Specificity

Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons.
Target Synonyms

Colorectal carcinoma associated protein; Colorectal carcinoma-associated protein; DKFZp762B1512; FLJ21439; KIAA1840; Spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11; Spastic paraplegia 11 protein; Spatacsin; SPG 11; Spg11; SPTCS_HUMAN
Target Background

The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human SPG11 Polyclonal Antibody

Specifications

Immunogen Information

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