Rabbit anti-Human SPIN1 Polyclonal Antibody

The antibody against SPIN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human SPIN1 (NP_006708.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-03643A

Number

Cat.No	ADA-03643A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SPIN1
Target Synonyms	SPIN; TDRD24; SPIN1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, HepG2, Jurkat, MCF7, Mouse brain, SH-SY5Y, SW480	Application	ELISA, WB, IHC-P

Cat.No

ADA-03643A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SPIN1

Target Synonyms

SPIN; TDRD24; SPIN1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, HepG2, Jurkat, MCF7, Mouse brain, SH-SY5Y, SW480

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human SPIN1 (NP_006708.2).	Target Species	Human
Uniprot ID	Q9Y657	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human SPIN1 (NP_006708.2).

Target Species

Human

Uniprot ID

Q9Y657

Immunogen Sequence

Background Information

Uniprot Id

Q9Y657
Target Species

Human
Target Name

SPIN1
Target Full Name

Spindlin-1
Target Function

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Target Subcellular Location

Nucleus. Nucleus, nucleolus.
Target Protein Families

SPIN/STSY family
Target Tissue Specificity

Highly expressed in ovarian cancer tissues.
Target Research Area

Cell Biology
Target Synonyms

OCR; Ovarian cancer-related protein; SPIN; Spin1; SPIN1_HUMAN; Spindlin-1
Target Background

Enables methylated histone binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of transcription, DNA-templated; and rRNA transcription. Located in cytosol and nucleus.

Rabbit anti-Human SPIN1 Polyclonal Antibody

Specifications

Immunogen Information

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