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The antibody against SUPV3L1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against SUPV3L1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-08893A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SUPV3L1 |
| Target Synonyms | SUV3; SUPV3L1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, Jurkat, K-562, Mouse liver, Raji, SW620 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8IYB8 | Immunogen Sequence |
Uniprot Id
Q8IYB8
Target Species
Human
Target Name
SUPV3L1
Target Full Name
ATP-dependent RNA helicase SUPV3L1, mitochondrial
Target Function
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Target Subcellular Location
Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
Target Protein Families
Helicase family
Target Tissue Specificity
Broadly expressed.
Target Synonyms
6330443E10Rik ; ATP dependent RNA helicase SUPV3L1; mitochondrial; ATP-dependent RNA helicase SUPV3L1; EC 3.6.1.; MGC109049; mitochondrial; OTTHUMP00000019719; S. Cerevisiae suppressor of var 1 3 like 1; suppressor of var1 (S.cerevisiae) 3 like 1; Suppressor of var1 3 like 1 (S. cerevisiae); Suppressor of var1 3 like 1 (S. cerevisiae)(SUV3); Suppressor of var1 3 like 1; Suppressor of var1 3 like protein 1; Suppressor of var1 3-like protein 1; SUPV 3 L 1; SUPV3L1; SUV 3; SUV 3 L 1; SUV3; SUV3 like protein 1; SUV3-like protein 1; SUV3_HUMAN; SUV3L1
Target Background
Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome.
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