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The antibody against Syntaxin 4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human Syntaxin 4 (NP_004595.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Syntaxin 4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human Syntaxin 4 (NP_004595.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09767A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Syntaxin 4 |
| Target Synonyms | STX4A; p35-2; Syntaxin 4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | NIH/3T3, A375, COS-1, HL-60, MCF7, Mouse liver, NCI-H460 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human Syntaxin 4 (NP_004595.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q12846 | Immunogen Sequence |
Uniprot Id
Q12846
Target Species
Human
Target Name
STX4
Target Full Name
Syntaxin-4
Target Function
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.
Target Subcellular Location
Cell membrane; Single-pass type IV membrane protein. Cell projection, neuron projection.
Target Protein Families
Syntaxin family
Target Tissue Specificity
Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.
Target Synonyms
NY REN 31 antigen; p35 2; PLACENTAL; Renal carcinoma antigen NY REN 31; Renal carcinoma antigen NY-REN-31; Stx4; STX4_HUMAN; STX4A; Syntaxin 4; syntaxin 4A (placental); Syntaxin 4A; Syntaxin-4
Target Background
Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse.
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