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The antibody against TCAP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_003664.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TCAP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_003664.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06175A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TCAP |
| Target Synonyms | TELE; CMD1N; CMH25; T-cap; LGMD2G; LGMDR7; telethonin; TCAP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T transfected with TCAP | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_003664.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG | Uniprot ID | O15273 |
Uniprot Id
O15273
Target Species
Human
Target Name
TCAP
Target Full Name
Telethonin
Target Function
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Target Involvement
Cardiomyopathy, familial hypertrophic 25 (CMH25); Limb-girdle muscular dystrophy 2G (LGMD2G)
Target Subcellular Location
Cytoplasm, myofibril, sarcomere.
Target Tissue Specificity
Heart and skeletal muscle.
Target Research Area
Cardiovascular
Target Synonyms
19 kDa sarcomeric protein; CMD1N; CMH25; LGMD2G; Limb girdle muscular dystrophy 2G (autosomal recessive); T-cap; Tcap; TELE; Telethonin; TELT_HUMAN; Titin cap protein; Titin-cap
Target Background
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
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