Rabbit anti-Human TFR2 Polyclonal Antibody

Uniprot Id

Q9UP52

Target Species

Human

Target Name

TFR2

Target Full Name

Transferrin receptor protein 2

Target Function

Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.

Target Involvement

Hemochromatosis 3 (HFE3)

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.; [Isoform Beta]: Cytoplasm. Note=Lacks the transmembrane domain. Probably intracellular.

Target Protein Families

Peptidase M28 family, M28B subfamily

Target Tissue Specificity

Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.

Target Synonyms

HFE 3; HFE3; MGC126368; TFR 2; TfR2; TFR2_HUMAN; TFRC 2; TFRC2; Transferrin receptor 2; Transferrin receptor protein 2

Target Background

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.