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The antibody against TRA2B was raised in Rabbit using a synthetic peptide of human TRA2B as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against TRA2B was raised in Rabbit using a synthetic peptide of human TRA2B as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-08919A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRA2B |
| Target Synonyms | SFRS10; SRFS10; TRAN2B; PPP1R156; TRA2-BETA; Htra2-beta; TRA2B | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293F, Molt-4, Mouse brain | Application | ELISA, WB, IF/ICC |
| Immunogen Description | A synthetic peptide of human TRA2B | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P62995 |
Uniprot Id
P62995
Target Species
Human
Target Name
TRA2B
Target Full Name
Transformer-2 protein homolog beta
Target Function
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
Target Subcellular Location
Nucleus.
Target Protein Families
Splicing factor SR family
Target Tissue Specificity
Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
arginine/serine-rich 10; Arginine/serine-rich splicing factor 10; hTRA2-beta; SFRS10; Splicing factor; Splicing factor arginine/serine rich 10; SRFS10; TRA-2 beta; TRA2-beta; Tra2b; TRA2B_HUMAN; TRAN2B; Transformer 2 beta homolog; Transformer-2 protein homolog B; Transformer-2 protein homolog beta; Transformer-2-beta
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