Rabbit anti-Human TRDMT1 Polyclonal Antibody

The antibody against TRDMT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 192-391 of human TRDMT1 (NP_004403.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-10929A

Number

Cat.No	ADA-10929A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TRDMT1
Target Synonyms	DMNT2; DNMT2; PUMET; RNMT1; MHSAIIP; TRDMT1	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, DU145, NCI-H460, SKOV3	Application	ELISA, WB

Cat.No

ADA-10929A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TRDMT1

Target Synonyms

DMNT2; DNMT2; PUMET; RNMT1; MHSAIIP; TRDMT1

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, DU145, NCI-H460, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 192-391 of human TRDMT1 (NP_004403.1).	Target Species	Human
Immunogen Sequence	VHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE	Uniprot ID	O14717

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 192-391 of human TRDMT1 (NP_004403.1).

Target Species

Human

Immunogen Sequence

VHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE

Uniprot ID

O14717

Background Information

Uniprot Id

O14717
Target Species

Human
Target Name

TRDMT1
Target Full Name

tRNA (cytosine(38)-C(5))-methyltransferase
Target Function

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Target Subcellular Location

Cytoplasm.
Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Target Tissue Specificity

Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
Target Synonyms

dDNMT; DmMT 2; DmMT2; DNA (cytosine 5 ) methyltransferase 2; DNA (cytosine 5) methyltransferase like protein 2; DNA (cytosine-5)-methyltransferase-like protein 2; DNA 5 cytosine methyltransferase; DNA methyltransferase 2; DNA methyltransferase homolog HsaIIP; DNA MTase homolog HsaIIP; Dnmt 2; Dnmt2; M.HsaIIP; MHsaIIP; nmt 2; nmt2; OTTHUMP00000045198; PuMet; RNMT 1; RNMT1; TRDMT 1; TRDMT_HUMAN; TRDMT1; tRNA (cytosine 5 ) methyltransferase; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA aspartic acid methyltransferase 1; tRNA aspartic acid methyltransferase 1 variant 1; tRNA aspartic acid methyltransferase 1 variant 2; tRNA aspartic acid methyltransferase 1 variant 3; tRNA aspartic acid methyltransferase 1 variant 4; tRNA aspartic acid methyltransferase 1 variant 5; tRNA aspartic acid methyltransferase 1 variant 8
Target Background

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa.

Rabbit anti-Human TRDMT1 Polyclonal Antibody

Specifications

Immunogen Information

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