Rabbit anti-Human TRPC4 Polyclonal Antibody

The antibody against TRPC4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_057263.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02753A

Number

Cat.No	ADA-02753A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TRPC4
Target Synonyms	TRP4; HTRP4; HTRP-4; TRPC4	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, BT-474, Mouse brain, SKOV3	Application	ELISA, WB

Cat.No

ADA-02753A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TRPC4

Target Synonyms

TRP4; HTRP4; HTRP-4; TRPC4

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, BT-474, Mouse brain, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_057263.1).	Target Species	Human
Uniprot ID	Q9UBN4	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_057263.1).

Target Species

Human

Uniprot ID

Q9UBN4

Immunogen Sequence

Background Information

Uniprot Id

Q9UBN4
Target Species

Human
Target Name

TRPC4
Target Full Name

Short transient receptor potential channel 4
Target Function

Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Target Subcellular Location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.
Target Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC4 sub-subfamily
Target Tissue Specificity

Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
Target Synonyms

CCE1; HTRP 4; hTrp-4; hTrp4; MGC119570; MGC119571; MGC119572; MGC119573; RP11-10M8.1; Short transient receptor potential channel 4; STRPC4; Transient receptor potential 4; transient receptor potential cation channel subfamily C; Transient receptor potential cation channel subfamily C member 4; transient receptor potential channel 4; TRP 4; trp related protein 4; Trp-related protein 4; TRP4; TRPC 4; TrpC4; TRPC4 protein; TRPC4_HUMAN
Target Background

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Rabbit anti-Human TRPC4 Polyclonal Antibody

Specifications

Immunogen Information

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