Rabbit anti-Human TRPM8 Monoclonal Antibody

Uniprot Id

Q7Z2W7

Target Species

Human

Target Name

TRPM8

Target Full Name

Transient receptor potential cation channel subfamily M member 8

Target Function

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane.

Target Protein Families

Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM8 sub-subfamily

Target Tissue Specificity

Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors.

Target Synonyms

Long transient receptor potential channel 6; LTrpC-6; LTrpC6; MGC2849; Short form of the TRPM8 cationic channel ; Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; transient receptor potential-p8; Trp p8; Trp-p8; Trpm8; TRPM8_HUMAN; TRPP8

Target Background

Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane.