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The antibody against TTLL12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-450 of human TTLL12 (NP_055955.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TTLL12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-450 of human TTLL12 (NP_055955.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01607A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TTLL12 |
| Target Synonyms | dJ526I14.2; TTLL12 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-450 of human TTLL12 (NP_055955.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14166 | Immunogen Sequence |
Uniprot Id
Q14166
Target Species
Human
Target Name
TTLL12
Target Full Name
Tubulin--tyrosine ligase-like protein 12
Target Function
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
Target Subcellular Location
Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus.
Target Tissue Specificity
Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions.
Target Synonyms
dJ526I14.2; FLJ41795; KIAA0153; TTL12_HUMAN; TTLL12; Tubulin tyrosine ligase like family; member 12; Tubulin--tyrosine ligase-like protein 12
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