Rabbit anti-Human TWF1 Polyclonal Antibody

Uniprot Id

Q12792

Target Species

Human

Target Name

TWF1

Target Full Name

Twinfilin-1

Target Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.

Target Involvement

Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton.

Target Protein Families

Actin-binding proteins ADF family, Twinfilin subfamily

Target Tissue Specificity

Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.

Target Synonyms

A6; A6 protein tyrosine kinase; MGC105817; MGC23788; MGC41876; Protein A6; Protein tyrosine kinase 9; PTK9; PTK9 protein tyrosine kinase 9; TWF 1; twf1; TWF1_HUMAN; Twinfilin 1; Twinfilin actin binding protein, homolog 1; Twinfilin; Twinfilin, actin-binding protein, homolog 1 (Drosophila); Twinfilin, Drosophila, homolog of, 1; Twinfilin-1

Target Background

This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.