Rabbit anti-Human TYMS Polyclonal Antibody

The antibody against TYMS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human TYMS (NP_001062.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-10360A

Number

Cat.No	ADA-10360A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TYMS
Target Synonyms	TS; TMS; DKCD; HST422; TYMS	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293F, Molt-4, T-47D	Application	ELISA, WB, IHC-P

Cat.No

ADA-10360A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TYMS

Target Synonyms

TS; TMS; DKCD; HST422; TYMS

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293F, Molt-4, T-47D

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human TYMS (NP_001062.1).	Target Species	Human
Uniprot ID	P04818	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human TYMS (NP_001062.1).

Target Species

Human

Uniprot ID

P04818

Immunogen Sequence

Background Information

Uniprot Id

P04818
Target Species

Human
Target Name

TYMS
Target Full Name

Thymidylate synthase
Target Function

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Target Subcellular Location

Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
Target Protein Families

Thymidylate synthase family
Target Synonyms

d TMP synthase; EC 2.1.1.45; HsT422; MGC88736; OTTHUMP00000162195; Thymidylate synthase; Thymidylate synthetase; TMS; TS; TSase; Tyms; TYMS protein; Tyms thymidylate synthetase; TYSY_HUMAN
Target Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

Rabbit anti-Human TYMS Polyclonal Antibody

Specifications

Immunogen Information

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