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The antibody against UGDH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against UGDH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of paraffin-embedded rat liver using UGDH antibody at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-06179A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UGDH |
| Target Synonyms | GDH; UGD; DEE84; EIEE84; UDPGDH; UDP-GlcDH; UGDH | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O60701 | Immunogen Sequence |
Uniprot Id
O60701
Target Species
Human
Target Name
UGDH
Target Full Name
UDP-glucose 6-dehydrogenase
Target Function
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development.
Target Protein Families
UDP-glucose/GDP-mannose dehydrogenase family
Target Tissue Specificity
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon. Widely expressed.
Target Synonyms
GDH; UDP Glc dehydrogenase; UDP GlcDH; UDP glucose 6 dehydrogenase; UDP glucose dehydrogenase; UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; UDPGDH; UGD; Ugdh; UGDH_HUMAN; Uridine diphospho glucose dehydrogenase
Target Background
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
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