Rabbit anti-Human WSTF Polyclonal Antibody

Uniprot Id

Q9UIG0

Target Species

Human

Target Name

BAZ1B

Target Full Name

Tyrosine-protein kinase BAZ1B

Target Function

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication.

Target Involvement

BAZ1B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BAZ1B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Target Subcellular Location

Nucleus.

Target Protein Families

WAL family, BAZ1B subfamily

Target Tissue Specificity

Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.

Target Synonyms

baz1b; BAZ1B_HUMAN; Bromodomain adjacent to zinc finger domain protein 1B; hWALP 2; hWALP-2; hWALP2; transcription factor WSTF; Tyrosine-protein kinase BAZ1B; WALP-2; WALP2; WBRS 9; WBRS-9; WBRS9; WBSC 10; WBSC-10; WBSC10; WBSCR10; WBSCR9; Williams Beuren syndrome chromosome region 9 protein; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; WSTF

Target Background

This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.