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The antibody against ZP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human ZP1 (NP_997224.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human ZP1 (NP_997224.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10941A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZP1 |
| Target Synonyms | OOMD; ZPB1; OOMD1; HEL163; OZEMA1; ZP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, Mouse lung, NCI-H460, OVCAR3, OVCAR8, Rat lung, Rat ovary, SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human ZP1 (NP_997224.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P60852 | Immunogen Sequence |
Uniprot Id
P60852
Target Species
Human
Target Name
ZP1
Target Full Name
Zona pellucida sperm-binding protein 1
Target Function
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
Target Involvement
Oocyte maturation defect 1 (OOMD1)
Target Subcellular Location
[Processed zona pellucida sperm-binding protein 1]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
Target Protein Families
ZP domain family, ZPB subfamily
Target Tissue Specificity
Expressed in oocytes (at protein level).
Target Synonyms
MGC87693; Processed zona pellucida sperm-binding protein 1; zona pellucida glycoprotein 1 (sperm receptor); Zona pellucida glycoprotein 1; zona pellucida protein 1; Zp 1; Zp-1; Zp1; ZP1_HUMAN
Target Background
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility.
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