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The antibody against MARCKSL1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 95-195 of human MARCKSL1 (NP_075385.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MARCKSL1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 95-195 of human MARCKSL1 (NP_075385.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using MARCKSL1 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
| Cat.No | ADA-08243A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MARCKSL1 |
| Target Synonyms | MARCKSL1; F52; MACMARCKS; MLP; MLP1; MRP; MARCKS like 1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Mouse thymus, Rat testis, SH-SY5Y | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 95-195 of human MARCKSL1 (NP_075385.1). | Immunogen Sequence | KKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPSGPESGPTPASAEQNE |
|---|---|---|---|
| Uniprot ID | P49006 |
Uniprot Id
P49006
Target Species
Human
Target Name
MARCKSL1
Target Full Name
MARCKS-related protein
Target Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
Target Protein Families
MARCKS family
Target Research Area
Signal Transduction
Target Synonyms
F52; Mac MARCKS ; Mac-MARCKS; MacMARCKS; Macrophage enriched Myristoylated Alanine Rich C Kinase Substrate Like Protein; Macrophage myristoylated alanine-rich C kinase substrate; MARCKS like 1; MARCKS like protein 1; MARCKS related protein ; MARCKS-like protein 1; MARCKS-related protein; MARCKSL1; MLP; MLP1; MRP; MRP_HUMAN
Target Background
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10.
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