Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)(I148M)

Uniprot Id

Q9NST1

Target Species

Human

Target Name

PNPLA3

Target Full Name

1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

Target Function

Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. Has hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety.

Target Involvement

Non-alcoholic fatty liver disease 1 (NAFLD1)

Target Subcellular Location

Membrane; Single-pass type II membrane protein. Lipid droplet.

Target Research Area

Cardiovascular

Target Synonyms

PNPLA3; ADPN; C22orf20; 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; EC 2.3.1.51; Acylglycerol transacylase; Adiponutrin; ADPN; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; Lysophosphatidic acid acyltransferase; Patatin-like phospholipase domain-containing protein 3; EC 3.1.1.3

Target Background

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.