Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1), Truncated

Uniprot Id

Q9P212

Target Species

Human

Target Name

PLCE1

Target Full Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Target Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly

Target Involvement

Nephrotic syndrome 3 (NPHS3)

Target Subcellular Location

Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.

Target Tissue Specificity

Widely expressed. Expressed in podocytes.; [Isoform 1]: Broadly expressed and only absent in peripheral blood leukocytes.; [Isoform 2]: Specifically expressed in placenta, lung and spleen.

Target Synonyms

1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase epsilon-1; Pancreas-enriched phospholipase C; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1; Plce1; PLCE1_HUMAN