Recombinant Human 14-3-3 protein beta/alpha (YWHAB)

Uniprot Id

P31946

Target Species

Human

Target Name

YWHAB

Target Full Name

14-3-3 protein beta/alpha

Target Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.

Target Subcellular Location

Cytoplasm. Melanosome.

Target Protein Families

14-3-3 family

Target Research Area

Signal Transduction

Target Synonyms

14 3 3; 14 3 3 protein beta; 14 3 3 protein beta/alpha; 14 3 3 protein zeta; 14 3 3 zeta; 14-3-3 protein beta/alpha; 14-3-3 protein/cytosolic phospholipase A2; 1433B_HUMAN; GW128; HS1; KCIP 1; KCIP-1; MGC111427; MGC126532; MGC138156; N-terminally processed; Protein 1054; Protein kinase C inhibitor protein 1; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; delta polypeptide; Tyrosine 3/tryptophan 5 -monooxygenase activation protein; zeta polypeptide; YWHAB; YWHAD; YWHAZ

Target Background

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.