Recombinant Human 2-5-oligoadenylate synthase-like protein (OASL)

Uniprot Id

Q15646

Target Species

Human

Target Name

OASL

Target Full Name

2'-5'-oligoadenylate synthase-like protein

Target Function

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Target Subcellular Location

[Isoform p56]: Nucleus, nucleolus. Cytoplasm.; [Isoform p30]: Cytoplasm.

Target Protein Families

2-5A synthase family

Target Tissue Specificity

Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Target Research Area

Cell Biology

Target Synonyms

2' 5' oligoadenylate synthetase like; 2''-5''-OAS-related protein; 2''-5''-OAS-RP; 2''-5''-oligoadenylate synthase-like protein; 2'-5' oligoadenylate synthetase-like 2; 2'-5'-oligoadenylate synthetase-like; 59 kDa 2' 5' oligoadenylate synthetase like protein; 59 kDa 2''-5''-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; M1204; Mmu-OASL; OASL; OASL_HUMAN; Oasl2; p59 OASL; p59OASL; THYROID HORMONE RECEPTOR INTERACTOR 14; Thyroid receptor interacting protein 14; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; TRIP14

Target Background

Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm.