Recombinant Human 28S ribosomal protein S15, mitochondrial (MRPS15)

Uniprot Id

P82914

Target Species

Human

Target Name

MRPS15

Target Full Name

Small ribosomal subunit protein uS15m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uS15 family

Target Synonyms

28S ribosomal protein S15; 28S ribosomal protein S15, mitochondrial [Precursor]; DC37; FLJ11564; mitochondrial; mitochondrial ribosomal protein S15; MPR S15; MRP-S15; MRPS15; RPMS15; RT15_HUMAN; S15mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q.