Recombinant Human 28S ribosomal protein S25, mitochondrial (MRPS25)

Uniprot Id

P82663

Target Species

Human

Target Name

MRPS25

Target Full Name

Small ribosomal subunit protein mS25

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mS25 family

Target Synonyms

MRPS25; RPMS25; 28S ribosomal protein S25; mitochondrial; MRP-S25; S25mt; Mitochondrial small ribosomal subunit protein mS25

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants.