Recombinant Human 28S ribosomal protein S30, mitochondrial (MRPS30)

Uniprot Id

Q9NP92

Target Species

Human

Target Name

MRPS30

Target Full Name

Large ribosomal subunit protein mL65

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL65 family

Target Tissue Specificity

Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes.

Target Synonyms

28S ribosomal protein S30; 28S ribosomal protein S30; mitochondrial; Mitochondrial 28S ribosomal protein S30; mitochondrial; Mitochondrial ribosomal protein S30; MRP S30; MRP-S30; MRPS30; PAP; PDCD9; Programmed cell death 9; Programmed cell death protein 9; RT30_HUMAN; S30mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.