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Recombinant Human 3-hydroxyacyl-CoA dehydratase 4 (PTPLAD2), Truncated

ACP08286

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP08286 Target NameHACD4
Target SynonymsHACD4; PTPLAD2; Very-long-chain; 3R-3-hydroxyacyl-CoA dehydratase 4; 3-hydroxyacyl-CoA dehydratase 4; HACD4; Protein-tyrosine phosphatase-like A domain-containing protein 2FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Protein LengthPartial
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ5VWC8
Background Information
  • Uniprot Id

    Q5VWC8

  • Target Species

    Human

  • Target Name

    HACD4

  • Target Full Name

    Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4

  • Target Function

    Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

  • Target Subcellular Location

    Endoplasmic reticulum membrane; Multi-pass membrane protein.

  • Target Protein Families

    Very long-chain fatty acids dehydratase HACD family

  • Target Tissue Specificity

    Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta.

  • Target Synonyms

    HACD4; PTPLAD2; Very-long-chain; 3R-3-hydroxyacyl-CoA dehydratase 4; 3-hydroxyacyl-CoA dehydratase 4; HACD4; Protein-tyrosine phosphatase-like A domain-containing protein 2

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