Recombinant Human 39S ribosomal protein L18, mitochondrial (MRPL18)

Uniprot Id

Q9H0U6

Target Species

Human

Target Name

MRPL18

Target Full Name

Large ribosomal subunit protein uL18m

Target Function

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uL18 family

Target Synonyms

39S ribosomal protein L18; 39S ribosomal protein L18 mitochondrial ; 39S ribosomal protein L18; mitochondrial precursor; HSPC071; L18mt; mitochondrial; Mitochondrial ribosomal protein L18 ; Mitochondrial ribosomal protein L18 (MRPL18 protein); MRP-L18; Mrpl18; RM18_HUMAN; RP1 195P10.3 001

Target Background

This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16.