Recombinant Human 39S ribosomal protein L3, mitochondrial (MRPL3)

Uniprot Id

P09001

Target Species

Human

Target Name

MRPL3

Target Full Name

Large ribosomal subunit protein uL3m

Target Involvement

Combined oxidative phosphorylation deficiency 9 (COXPD9)

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uL3 family

Target Synonyms

39S ribosomal protein L3; 39S ribosomal protein L3 mitochondrial; COXPD9; L3mt; Mitochondrial 39S ribosomal protein L3; Mitochondrial 60S ribosomal protein L3; mitochondrial; mitochondrial ribosomal protein; Mitochondrial ribosomal protein L3; MRL3; MRP-L3; MRPL3; RM03_HUMAN; RPML3

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.