Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

Dive into the field of neuroscience with our Recombinant Human ABAT protein, a key enzyme involved in the breakdown and synthesis of neurotransmitters. This mitochondrial 4-aminobutyrate aminotransferase is encoded by the human ABAT (GABAT) gene and represents the full length of the mature protein, derived from the 29-500aa expression region. Produced in E.coli, this high-quality recombinant protein features N-terminal 10xHis-SUMO and C-terminal Myc tags for ease of purification and detection. With a purity of greater than 90% as determined by SDS-PAGE, the Recombinant Human ABAT protein is provided as a lyophilized powder, ensuring reliable performance for your research applications.

ACP02357

Dive into the field of neuroscience with our Recombinant Human ABAT protein, a key enzyme involved in the breakdown and synthesis of neurotransmitters. This mitochondrial 4-aminobutyrate aminotransferase is encoded by the human ABAT (GABAT) gene and represents the full length of the mature protein, derived from the 29-500aa expression region.
Produced in E.coli, this high-quality recombinant protein features N-terminal 10xHis-SUMO and C-terminal Myc tags for ease of purification and detection. With a purity of greater than 90% as determined by SDS-PAGE, the Recombinant Human ABAT protein is provided as a lyophilized powder, ensuring reliable performance for your research applications.

Number

Cat.No	ACP02357	Target Name	ABAT
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	29-500aa	Mol Weight	73.3kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02357

Target Name

ABAT

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

29-500aa

Mol Weight

73.3kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P80404

Background Information

Uniprot Id

P80404
Target Species

Human
Target Name

ABAT
Target Full Name

4-aminobutyrate aminotransferase, mitochondrial
Target Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Target Involvement

GABA transaminase deficiency (GABATD)
Target Subcellular Location

Mitochondrion matrix.
Target Protein Families

Class-III pyridoxal-phosphate-dependent aminotransferase family
Target Tissue Specificity

Liver > pancreas > brain > kidney > heart > placenta.
Target Research Area

Neuroscience
Target Synonyms

(S) 3 amino 2 methylpropionate transaminase ; (S)-3-amino-2-methylpropionate transaminase; 4 aminobutyrate aminotransferase; 4 aminobutyrate aminotransferase; mitochondrial; 4-aminobutyrate aminotransferase; ABAT; FLJ17813; FLJ30272; GABA aminotransferase; GABA AT; GABA T; GABA transaminase; GABA transferase; GABA-AT; GABA-T; GABAT; GABT_HUMAN; Gamma amino N butyrate transaminase; Gamma-amino-N-butyrate transaminase; hCG1984265; L AIBAT; L-AIBAT; LAIBAT; mitochondrial; NPD009
Target Background

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

Specifications

Immunogen Information

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