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| Cat.No | ACP15034 | Target Name | ASPM |
|---|---|---|---|
| Target Synonyms | ASPM; MCPH5; Abnormal spindle-like microcephaly-associated protein; Abnormal spindle protein homolog; Asp homolog | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IZT6 |
|---|
Uniprot Id
Q8IZT6
Target Species
Human
Target Name
ASPM
Target Full Name
Abnormal spindle-like microcephaly-associated protein
Target Function
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis.
Target Involvement
Microcephaly 5, primary, autosomal recessive (MCPH5)
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus.
Target Synonyms
ASPM; MCPH5; Abnormal spindle-like microcephaly-associated protein; Abnormal spindle protein homolog; Asp homolog
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