Recombinant Human Acetyl-CoA carboxylase 1 (ACACA), Truncated

Cat.No	ACP18086	Target Name	ACACA
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18086

Target Name

ACACA

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q13085

Background Information

Uniprot Id

Q13085
Target Species

Human
Target Name

ACACA
Target Full Name

Acetyl-CoA carboxylase 1
Target Function

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
Target Involvement

Acetyl-CoA carboxylase 1 deficiency (ACACAD)
Target Subcellular Location

Cytoplasm, cytosol.
Target Tissue Specificity

Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Target Research Area

Cancer
Target Synonyms

ACAC; ACACA; ACACA_HUMAN; ACACB; ACC alpha; ACC; ACC beta ; ACC-alpha; ACC1; ACC2; ACCA; ACCB; Acetyl CoA carboxylase 1; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase alpha ; Acetyl CoA carboxylase beta; Acetyl Coenzyme A carboxylase alpha; Acetyl Coenzyme A carboxylase beta; Biotin carboxylase; COA1; COA2; HACC275; OTTHUMP00000164069; OTTHUMP00000164070; OTTHUMP00000164076; OTTHUMP00000240532
Target Background

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Recombinant Human Acetyl-CoA carboxylase 1 (ACACA), Truncated

Specifications

Immunogen Information

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