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Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1) is a partial length protein expressed with an N-terminal 6xHis-tagged in the E.coli. Its expression region corresponds to 21-255aa (Extracellular Domain) of human CHRNA1 protein. It underwent validation via the LC-MS/MS analysis. Its purity reached up to 90% determined by SDS-PAGE. Under reducing conditions, a molecular weight band of around 32 kDa was visualized on the gel. This recombinant CHRNA1 protein is in stock now. CHRNA1 is a component of acetylcholine receptors (AChRs) that are neurotransmitter receptors in the neuronal system. This protein plays a role in acetlycholine binding/channel gating. The ACh/AChR signaling is essential to normal the central nervous system (CNS) function. Alterations in this signaling lead to multiple neuropsychiatric disorders, including Myasthenic Syndrome, Congenital, 1B, Fast-Channel and Myasthenic Syndrome, Congenital, 1A, Slow-Channel.
Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1) is a partial length protein expressed with an N-terminal 6xHis-tagged in the E.coli. Its expression region corresponds to 21-255aa (Extracellular Domain) of human CHRNA1 protein. It underwent validation via the LC-MS/MS analysis. Its purity reached up to 90% determined by SDS-PAGE. Under reducing conditions, a molecular weight band of around 32 kDa was visualized on the gel. This recombinant CHRNA1 protein is in stock now.
CHRNA1 is a component of acetylcholine receptors (AChRs) that are neurotransmitter receptors in the neuronal system. This protein plays a role in acetlycholine binding/channel gating. The ACh/AChR signaling is essential to normal the central nervous system (CNS) function. Alterations in this signaling lead to multiple neuropsychiatric disorders, including Myasthenic Syndrome, Congenital, 1B, Fast-Channel and Myasthenic Syndrome, Congenital, 1A, Slow-Channel.
| Cat.No | ACP02518 | Target Name | CHRNA1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 21-255aa | Mol Weight | 31.1kDa |
| Protein Length | Partial of P02708-1 | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P02708 |
|---|
Uniprot Id
P02708
Target Species
Human
Target Name
CHRNA1
Target Full Name
Acetylcholine receptor subunit alpha
Target Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Target Involvement
Multiple pterygium syndrome, lethal type (LMPS); Myasthenic syndrome, congenital, 1A, slow-channel (CMS1A); Myasthenic syndrome, congenital, 1B, fast-channel (CMS1B)
Target Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-1/CHRNA1 sub-subfamily
Target Tissue Specificity
Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
Target Research Area
Neuroscience, Transport
Target Synonyms
Acetylcholine receptor subunit alpha; ACHA_HUMAN; AChR; ACHRA; ACHRD; CHNRA; Cholinergic receptor nicotinic alpha 1 subunit; Cholinergic receptor nicotinic alpha polypeptide 1; Cholinergic receptor; nicotinic; alpha polypeptide 1 (muscle); Chrna1; CMS1A; CMS1B; CMS2A; FCCMS; Nicotinic cholinergic receptor alpha 1; SCCMS; Schizophrenia neurophysiologic defect candidate
Target Background
The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.
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