Recombinant Human Acid-sensing ion channel 5 (ASIC5), Truncated

Uniprot Id

Q9NY37

Target Species

Human

Target Name

ASIC5

Target Full Name

Acid-sensing ion channel 5

Target Function

Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Amiloride-sensitive sodium channel (TC 1.A.6) family, ASIC5 subfamily

Target Tissue Specificity

Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum.

Target Synonyms

Acid-sensing ion channel 5; amiloride sensitive cation channel 5, intestinal; Amiloride sensitive sodium channel; Amiloride-sensitive cation channel 5; ASIC5; ASIC5_HUMAN; HINaC; Human intestine Na(+) channel; INAC

Target Background

This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known.